Difference between revisions of "Cephalosporins"

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==1st Generation==
 
==1st Generation==
* Cefazolin, [[Cephalexin]]
 
 
** Skin and soft tissue infections (why is agent of choice before gen sx)
 
** Skin and soft tissue infections (why is agent of choice before gen sx)
 
* [[Ceftriaxone_Cross-reactivity|Cross-reactivity of PCN]] allergy <10%
 
* [[Ceftriaxone_Cross-reactivity|Cross-reactivity of PCN]] allergy <10%
 
==2nd Generation==
 
==2nd Generation==
* Cefuroxime
 
 
** Intestinal anaerobes (why is agent of choice for colorectal sx)
 
** Intestinal anaerobes (why is agent of choice for colorectal sx)
 
** Largely displaced by 3rd gen agents
 
** Largely displaced by 3rd gen agents
 
==3rd Generation==
 
==3rd Generation==
*[[Ceftriaxone]], Ceftazidime, Cefixime
 
 
** Drug of choice for serious infections due to:
 
** Drug of choice for serious infections due to:
 
*** Klebsiella
 
*** Klebsiella
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** Pseudomonas meningitis (+ AG)
 
** Pseudomonas meningitis (+ AG)
 
==4th Generation==
 
==4th Generation==
* Cefepime
 
 
** Resistant, nosocomial infections
 
** Resistant, nosocomial infections
  

Revision as of 20:20, 26 March 2014

1st Generation

2nd Generation

    • Intestinal anaerobes (why is agent of choice for colorectal sx)
    • Largely displaced by 3rd gen agents

3rd Generation

    • Drug of choice for serious infections due to:
      • Klebsiella
      • Enterobacter
      • Proteus
      • Haemophilus
    • Gonorrhea
    • Lyme Disease
    • Meningitis (+ vanc and ampicillin)
    • Pseudomonas meningitis (+ AG)

4th Generation

    • Resistant, nosocomial infections

See Also

Source

Goodman & Gilman's Pharmacology