Cefprozil

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Administration

  • Type: 2nd generation cephalosporin
  • Dosage Forms: tablet, oral suspension
  • Dosage Strengths: tablet: 250mg, 500mg; oral suspension: 125mg/5mL, 250mg/5mL
  • Routes of Administration: PO
  • Common Trade Names: Cefzil

Adult Dosing

Infections, bacterial:

  • 250-500mg PO q12h x 10 days

Pediatric Dosing

infections, bacterial:

  • 30mg/kg/day PO divided q12h x 10 days, max 1000mg/day

Special Populations

Renal Dosing

  • Adult: CrCl < 30: decrease dose 50%
  • Pediatric:CrCl < 30: decrease dose 50%

Hepatic Dosing

  • Adult: none defined
  • Pediatric: none defined

Contraindications

  • Allergy to class/drug
  • PKU

Adverse Reactions

Serious

  • anaphylaxis
  • seizures
  • nephrotoxicity
  • leukopenia or thrombocytopenia
  • steven-johnson syndrome
  • c-diff associated diarrhea

Common

  • nausea
  • diarrhea
  • vomiting
  • transaminitis
  • dizziness
  • rash
  • eosinophilia

Pharmacology

  • Half-life: 1.3 h
  • Metabolism: hepatic
  • Excretion: unchanged in urine (61%)

Mechanism of Action

bactericidal, inhibits cell wall mucopeptide synthesis

Comments

See Also

References