Carvedilol

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Administration

  • Type: Beta-blocker
  • Dosage Forms:
  • Routes of Administration: oral
  • Common Trade Names: Coreg

Adult Dosing

  • 3.125-50mg BID

Pediatric Dosing

Safety/efficacy not established

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Infant risk cannot be ruled out
  • Renal dosing: no adjustment
  • Hepatic dosing: contraindicated in severe liver disease

Contraindications

  • Allergy to class/drug
  • Cardiogenic shock
  • Asthma or other bronchospastic condition
  • 2nd or 3rd degree AV block, severe bradycardia, sick sinus
  • Severe hepatic impairment

Adverse Reactions

Serious

  • AV block, bradyarrhythmia, hypotension
  • SJS/TEN
  • Aplastic anemia
  • Asthma with status asthmaticus
  • Intraoperative floppy iris syndrome (?!)

Common

  • Bradyarrhythmia, hypotension
  • Peripheral edema
  • Weight gain, hyperglycemia
  • Diarrhea
  • Dizziness, fatigue
  • Erectile dysfunction

Pharmacology

  • Half-life: 7-10h
  • Metabolism: Hepatic CYP2D6
  • Excretion: Fecal/biliary

Mechanism of Action

  • Nonselective beta-blocker with alpha-1 blocking activity

Comments

See Also

References