Difference between revisions of "Carvedilol"

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(edited dosage forms, strengths, routes of administration)
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==Administration==
 
==Administration==
 
*Type: Beta-blocker
 
*Type: Beta-blocker
*Dosage Forms: capsule, extended release: 10mg, 20mg, 40mg, 80mg; tablet: 3.125mg, 6.25mg, 12.5mg, 25mg
+
*Dosage Forms: extended-release capsule, tablet
*Routes of Administration: oral
+
*Dosage Strengths: capsule, extended release: 10mg, 20mg, 40mg, 80mg; tablet: 3.125mg, 6.25mg, 12.5mg, 25mg
 +
*Routes of Administration: PO
 
*Common Trade Names: Coreg
 
*Common Trade Names: Coreg
  

Revision as of 00:30, 12 October 2017

Administration

  • Type: Beta-blocker
  • Dosage Forms: extended-release capsule, tablet
  • Dosage Strengths: capsule, extended release: 10mg, 20mg, 40mg, 80mg; tablet: 3.125mg, 6.25mg, 12.5mg, 25mg
  • Routes of Administration: PO
  • Common Trade Names: Coreg

Adult Dosing

  • 3.125-50mg BID

Pediatric Dosing

Safety/efficacy not established

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Infant risk cannot be ruled out
  • Renal dosing: no adjustment
  • Hepatic dosing: contraindicated in severe liver disease

Contraindications

  • Allergy to class/drug
  • Cardiogenic shock
  • Asthma or other bronchospastic condition
  • 2nd or 3rd degree AV block, severe bradycardia, sick sinus
  • Severe hepatic impairment

Adverse Reactions

Serious

  • AV block, bradyarrhythmia, hypotension
  • SJS/TEN
  • Aplastic anemia
  • Asthma with status asthmaticus
  • Intraoperative floppy iris syndrome (?!)

Common

  • Bradyarrhythmia, hypotension
  • Peripheral edema
  • Weight gain, hyperglycemia
  • Diarrhea
  • Dizziness, fatigue
  • Erectile dysfunction

Pharmacology

  • Half-life: 7-10h
  • Metabolism: Hepatic CYP2D6
  • Excretion: Fecal/biliary

Mechanism of Action

  • Nonselective beta-blocker with α-1 blocking activity

Comments

See Also

References