Difference between revisions of "Carvedilol"

(Created page with "==Administration== *Type: Beta-blocker *Dosage Forms: *Routes of Administration: oral *Common Trade Names: Coreg ==Adult Dosing== *3.125-50mg BID ==Pediatric Dosing== ''Safet...")
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==Mechanism of Action==
==Mechanism of Action==
*Nonselective beta-blocker with alpha-1 blocking activity  
*Nonselective beta-blocker with α-1 blocking activity  

Revision as of 01:12, 24 July 2017


  • Type: Beta-blocker
  • Dosage Forms:
  • Routes of Administration: oral
  • Common Trade Names: Coreg

Adult Dosing

  • 3.125-50mg BID

Pediatric Dosing

Safety/efficacy not established

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Infant risk cannot be ruled out
  • Renal dosing: no adjustment
  • Hepatic dosing: contraindicated in severe liver disease


  • Allergy to class/drug
  • Cardiogenic shock
  • Asthma or other bronchospastic condition
  • 2nd or 3rd degree AV block, severe bradycardia, sick sinus
  • Severe hepatic impairment

Adverse Reactions


  • AV block, bradyarrhythmia, hypotension
  • Aplastic anemia
  • Asthma with status asthmaticus
  • Intraoperative floppy iris syndrome (?!)


  • Bradyarrhythmia, hypotension
  • Peripheral edema
  • Weight gain, hyperglycemia
  • Diarrhea
  • Dizziness, fatigue
  • Erectile dysfunction


  • Half-life: 7-10h
  • Metabolism: Hepatic CYP2D6
  • Excretion: Fecal/biliary

Mechanism of Action

  • Nonselective beta-blocker with α-1 blocking activity


See Also