Captopril

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Administration

  • Type: ACE-inhibitor
  • Dosage Forms:
  • Routes of Administration: Oral
  • Common Trade Names:

Adult Dosing

  • 6.25-150mg PO three times per day

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

Contraindications

  • Allergy to class/drug
  • History of ACE-inhibitor induced angioedema

Adverse Reactions

Serious

  • Angioedema
  • Stevens-Johnson syndrome
  • Agranulocytosis, neutropenia

Common

  • Hypotension
  • Hyperkalemia
  • Cough
  • Rash

Pharmacology

  • Half-life: < 3 hours
  • Metabolism:
  • Excretion: Renal, dialzable

Mechanism of Action

  • Inhibits angiotensin I-converting enzyme, blocks conversion of angiotensin I--> angiotensin II

Comments

See Also

References