Difference between revisions of "Captopril"
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==Administration== | ==Administration== | ||
*Type: [[ACE inhibitor]] | *Type: [[ACE inhibitor]] | ||
| − | *Dosage Forms: | + | *Dosage Forms: tablet |
| − | *Routes of Administration: | + | *Dosage Strengths: 12.5, 25, 50, 100mg |
| − | *Common Trade Names: | + | *Routes of Administration: PO |
| + | *Common Trade Names: Capoten, Captoril | ||
==Adult Dosing== | ==Adult Dosing== | ||
| Line 25: | Line 26: | ||
===Common=== | ===Common=== | ||
*Hypotension | *Hypotension | ||
| − | *Hyperkalemia | + | *[[Hyperkalemia]] |
*Cough | *Cough | ||
*Rash | *Rash | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: < 3 hours | *Half-life: < 3 hours | ||
| − | *Metabolism: | + | *Metabolism: Hepatic |
*Excretion: Renal, dialzable | *Excretion: Renal, dialzable | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
| − | *Inhibits angiotensin I-converting enzyme, blocks conversion of angiotensin | + | *Inhibits angiotensin I-converting enzyme, blocks conversion of angiotensin I→ angiotensin II |
==Comments== | ==Comments== | ||
| Line 41: | Line 42: | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| − | [[Category:Pharmacology]] | + | [[Category:Pharmacology]] [[Category:Cardiology]] |
Latest revision as of 21:43, 19 September 2019
Contents
Administration
- Type: ACE inhibitor
- Dosage Forms: tablet
- Dosage Strengths: 12.5, 25, 50, 100mg
- Routes of Administration: PO
- Common Trade Names: Capoten, Captoril
Adult Dosing
- 6.25-150mg PO three times per day
Pediatric Dosing
Safety/efficacy not established in pediatric patients
Special Populations
- Pregnancy Rating: D
- Lactation risk: Infant risk minimal
- Renal dosing: Initial dose should be reduced, titrate in smaller increments
Contraindications
- Allergy to class/drug
- History of ACE-inhibitor induced angioedema
Adverse Reactions
Serious
- Angioedema
- Stevens-Johnson syndrome
- Agranulocytosis, neutropenia
Common
- Hypotension
- Hyperkalemia
- Cough
- Rash
Pharmacology
- Half-life: < 3 hours
- Metabolism: Hepatic
- Excretion: Renal, dialzable
Mechanism of Action
- Inhibits angiotensin I-converting enzyme, blocks conversion of angiotensin I→ angiotensin II