Blood products

Revision as of 08:04, 5 February 2014 by Rossdonaldson1 (talk | contribs)

Fresh Frozen Plasma

Features

  1. Contains all coagulation factors and fibrinogen
    1. 40 mL/kg raises any factor by 100% (each unit is ~200mL)
  2. May cause fluid overload
  3. ABO compatibilty a must but crossmatch before transfusing not
  4. INR of FFP is ~1.2

Indications

  1. Rapid reversal of warfarin over-anticoagulation
  2. Bleeding and multiple coagulation defects
  3. Correction of coagulation defects for which no specific factor is available
  4. Transfusion of more than one blood volume w/ evidence of active bleeding + coagulopathy

Dose

  1. Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)

Cryoprecipitate Transfusion

Features

  1. Cold insoluble protein fraction of FFP
  2. Contains: fibrinogen, vWF, and factor VIII
  3. 1 bag (10ml) has 50-500 units of factor 8 activity

Indications

  1. Bleeding with fibrinogen level of <100 milligrams/dL
  2. Dysfibrinogenemia
  3. Bleeding in vWD that is unresponsive to DDAVP and Factor VIII is unavailable (can also use Humate-P, FFP doesn't work well)

Dose

  1. 1 unit/5kg (usually 10 units are given at a time)
    1. Will raise fibrinogen level by 75

Humate-P

Features

  1. Contains: vWF and factor VIII

Indications

  1. Hemophilia A (can also use factor VIII, FFP doesn't work well)
  2. vWD that is unresponsive to DDAVP (can also use cryo, FFP doesn't work well)

Dose

Depends on condition and severity of bleeding

See Also

Source

Tintinalli