Bleeding treatments

Treatments

1. pRBCs
2. DDAVP 0.3mg/kg subQ or IV (max 20mg)
3. Platelets
4. FFP
5. Cryopreticipate
6. Vitamin K (10mg SQ/IM)
7. Protamine (Heparin)
8. Estrogen (Uterine, renal)
9. PPI/Pepcid/Octreotide (GI)

Vitamin K Deficiency

1. FFP
2. Vitamin K (+/- takes 24hrs to affect & 2wk to wear off)

Warfarin

• See Warfarin (Coumadin) Reversal

Heparin/Lovenox

1. Protamie (1mg IV Q100 U of heparin in previous 4hrs)
2. Massive bleed --> cryoprecipitate (10 U IV), then FFP (& platelets, aminocaproic acid infusion if nec)

See Heparin (Unfractionated)

Liver Disease

See Coagulation Disorders

Renal Disease

See Coagulation Disorders

DIC

See DIC

Factor VIII Inhibitor

(PTT does not correct after mixing)

1. high dose Factor VII, prothrombin, or recombinant factor VIIa

Lupus Anticoagulant

(rare)

1. warfarin or ASA

See Also

• Hemophilia
• Coagulation Disorders

Source

1/22/06 DONALDSON (adapted from Tintinalli's)