Black widow spider bite: Difference between revisions
No edit summary |
ClaireLewis (talk | contribs) |
||
(23 intermediate revisions by 8 users not shown) | |||
Line 1: | Line 1: | ||
==Background== | ==Background== | ||
*Identification: red hourglass on otherwise black spider | |||
*Genus: ''Latrodectus'' | |||
[[File:Western Black Widow (Latrodectus hesperus).jpg|thumb|Black widow spider]] | [[File:Western Black Widow (Latrodectus hesperus).jpg|thumb|Black widow spider]] | ||
===Mechanism=== | ===Mechanism=== | ||
*α-Latrotoxin envenomation causes massive release of neurotransmitters (norepinephrine, dopamine, acetylcholine, glutamate and GABA) from the nerve terminals → muscle cramps, [[tachycardia]], [[hypertension]] | |||
*This clinical envenomation syndrome is known as ''latrodectism'' | |||
==Clinical Features== | ==Clinical Features== | ||
===Local=== | |||
===Local=== | |||
*Pinprick sensation; then increasing local pain that may spread to entire extremity | *Pinprick sensation; then increasing local pain that may spread to entire extremity | ||
*Erythema appears 20-60 min after the bite | *Erythema appears 20-60 min after the bite | ||
*Pain begins to abate after several hours and disappears by 2-3d | *Pain begins to abate after several hours and disappears by 2-3d | ||
===Systemic=== | ===Systemic=== | ||
*Muscle cramp-like spasms in large muscle groups (although exam rarely reveals rigidity) | *Muscle cramp-like spasms in large muscle groups (although exam rarely reveals rigidity) | ||
*Pain becomes generalized | *Pain becomes generalized | ||
**Severe abdominal wall musculature pain and cramping | **Severe [[abdominal pain|abdominal wall musculature pain]] and cramping | ||
*[[ | **Difficult to differentiate from [[peritonitis]] | ||
*[[Headache]], [[nausea/vomiting]], diaphoresis, photophobia, [[dyspnea]] | |||
*[[A-fib]], [[myocarditis]], [[priapism]], and death are rare | *[[A-fib]], [[myocarditis]], [[priapism]], and death are rare | ||
===Grading System=== | |||
*Grade 1: Range from no symptoms to local pain at the envenomation site with normal vital signs | |||
*Grade 2: Involve muscular pain at the envenomation site to migration to the trunk, diaphoresis at bite site and normal vital signs | |||
*Grade 3: Include grade 2 with abnormal vital signs; diaphoresis distant to envenomation site, generalized [[myalgia]] to back, chest and abdomen, nausea vomiting and headaches. | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{Bites and stings DDX}} | {{Bites and stings DDX}} | ||
== | ==Evaluation== | ||
* | *Generally clinical diagnosis | ||
==Management== | ==Management== | ||
* | *Local wound care, [[analgesia]] and [[tetanus prophylaxis]] are mainstays of treatment | ||
**Grade 1: Cold packs and | **Grade 1: Cold packs and [[NSAIDs]] | ||
**Grade 2/3: IV Opioids and | **Grade 2/3: IV [[Opioids]] and [[Benzodiazepines]] | ||
* | *[[Antivenin]] - indicated for systemic illness only | ||
** | **Dosage: Usual dose is one to two vials diluted in 50 to 100 mL 5% dextrose or 0.9% sodium chloride, then infused over 1 hour | ||
** | **Use is controversial - ''Morbidity'' (pain, cramping and autonomic disturbances) are high, but ''mortality'' is low. Antivenin is horse serum derived, and can lead to anaphylaxis and serum sickness | ||
**Consider for: Pediatric patients, pregnant women, elderly | |||
* | ===Not Indicated=== | ||
* | *Routine antibiotic use is not indicated | ||
*IV [[calcium gluconate]] to reduce muscle spasm is an outdated therapy not favored by toxicologists<ref>Clark RF et al. Clinical presentation and treatment of black widow spider envenomation: a review of 163 cases. Ann Emerg Med. 1992 Jul;21(7):782-7.</ref> | |||
==Disposition== | ==Disposition== | ||
*Generally may be discharged | |||
*Consider admission for: | *Consider admission for: | ||
**Symptoms of moderate envenomation | **Symptoms of moderate or severe envenomation | ||
**Pregnant women | **Pregnant women | ||
**Children | **Children | ||
** | **Preexisting cardiovascular disease or hypertension | ||
==See Also== | ==See Also== | ||
*[[ | *[[Envenomations, bites and stings]] | ||
==External Links== | ==External Links== | ||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category: | [[Category:Environmental]] | ||
[[Category: | [[Category:Dermatology]] |
Revision as of 17:23, 24 September 2019
Background
- Identification: red hourglass on otherwise black spider
- Genus: Latrodectus
Mechanism
- α-Latrotoxin envenomation causes massive release of neurotransmitters (norepinephrine, dopamine, acetylcholine, glutamate and GABA) from the nerve terminals → muscle cramps, tachycardia, hypertension
- This clinical envenomation syndrome is known as latrodectism
Clinical Features
Local
- Pinprick sensation; then increasing local pain that may spread to entire extremity
- Erythema appears 20-60 min after the bite
- Pain begins to abate after several hours and disappears by 2-3d
Systemic
- Muscle cramp-like spasms in large muscle groups (although exam rarely reveals rigidity)
- Pain becomes generalized
- Severe abdominal wall musculature pain and cramping
- Difficult to differentiate from peritonitis
- Headache, nausea/vomiting, diaphoresis, photophobia, dyspnea
- A-fib, myocarditis, priapism, and death are rare
Grading System
- Grade 1: Range from no symptoms to local pain at the envenomation site with normal vital signs
- Grade 2: Involve muscular pain at the envenomation site to migration to the trunk, diaphoresis at bite site and normal vital signs
- Grade 3: Include grade 2 with abnormal vital signs; diaphoresis distant to envenomation site, generalized myalgia to back, chest and abdomen, nausea vomiting and headaches.
Differential Diagnosis
Envenomations, bites and stings
- Hymenoptera stings (bees, wasps, ants)
- Mammalian bites
- Closed fist infection (Fight bite)
- Dog bite
- Marine toxins and envenomations
- Toxins (ciguatera, neurotoxic shellfish poisoning, paralytic shellfish poisoning, scombroid, tetrodotoxin
- Stingers (stingray injury)
- Venomous fish (catfish, zebrafish, scorpion fish, stonefish, cone shells, lionfish, sea urchins)
- Nematocysts (coral reef, fire coral, box jellyfish, sea wasp, portuguese man-of-war, sea anemones)
- Phylum porifera (sponges)
- Bites (alligator/crocodile, octopus, shark)
- Scorpion envenomation
- Reptile envenomation
- Spider bites
Evaluation
- Generally clinical diagnosis
Management
- Local wound care, analgesia and tetanus prophylaxis are mainstays of treatment
- Grade 1: Cold packs and NSAIDs
- Grade 2/3: IV Opioids and Benzodiazepines
- Antivenin - indicated for systemic illness only
- Dosage: Usual dose is one to two vials diluted in 50 to 100 mL 5% dextrose or 0.9% sodium chloride, then infused over 1 hour
- Use is controversial - Morbidity (pain, cramping and autonomic disturbances) are high, but mortality is low. Antivenin is horse serum derived, and can lead to anaphylaxis and serum sickness
- Consider for: Pediatric patients, pregnant women, elderly
Not Indicated
- Routine antibiotic use is not indicated
- IV calcium gluconate to reduce muscle spasm is an outdated therapy not favored by toxicologists[1]
Disposition
- Generally may be discharged
- Consider admission for:
- Symptoms of moderate or severe envenomation
- Pregnant women
- Children
- Preexisting cardiovascular disease or hypertension
See Also
External Links
References
- ↑ Clark RF et al. Clinical presentation and treatment of black widow spider envenomation: a review of 163 cases. Ann Emerg Med. 1992 Jul;21(7):782-7.