Balantidium coli: Difference between revisions
Vincent Chan (talk | contribs) (Linked ecoli) Tag: mobile edit |
(Text replacement - "qid" to "QID") |
||
(7 intermediate revisions by 3 users not shown) | |||
Line 1: | Line 1: | ||
==Background== | ==Background== | ||
*Infection of large intestine by parasite, '' | *Infection of large intestine by parasite, ''Balantidium coli'' | ||
** | **Large, ciliated protozoan | ||
** | **Simple life cycle: dormant cyst to trophozoite to cyst | ||
*Reservoir host is pig (asymptomatic) | *Reservoir host is pig (asymptomatic) | ||
*Pig sheds feces with cysts => contaminated water and food => ingested by humans => parasite resides in large intestine | *Pig sheds feces with cysts => contaminated water and food => ingested by humans => parasite resides in large intestine | ||
Line 8: | Line 8: | ||
**Opportunistic infection | **Opportunistic infection | ||
*Human-to-human transmission via fecal-oral route as well | *Human-to-human transmission via fecal-oral route as well | ||
*Worldwide prevalence 0.02-1% . | *Worldwide prevalence 0.02-1%<ref>Schuster FL and Ramirez-Avila L. Current World Status of Balantidium coli. Clin. Microbiol. 2008; 21(4):626–638.</ref> and found wherever pigs are found | ||
*Risk factors: | *Risk factors: | ||
**Close contact between human and pigs | **Close contact between human and pigs | ||
Line 34: | Line 34: | ||
*IBD | *IBD | ||
== | ==Evaluation== | ||
*Stool samples over several days (excretion of parasites can be erratic) | *Stool samples over several days (excretion of parasites can be erratic) | ||
*Wet mount slide preparation: large 150-200um ovoid shape with cilia, swimming aimlessly in circles | *Wet mount slide preparation: large 150-200um ovoid shape with cilia, swimming aimlessly in circles | ||
Line 40: | Line 40: | ||
==Management== | ==Management== | ||
*[[Metronidazole]] | *[[Metronidazole]] '''''OR''''' | ||
**Adults: 500-750mg tid x 5 days | **Adults: 500-750mg tid x 5 days | ||
**Peds: 35- | **Peds: 35-50mg/kg/day in 3 doses x 5 days (max: 2g/day) | ||
*Tetracycline | *[[Tetracycline]] '''''OR''''' | ||
**Adult: 500mg | **Adult: 500mg QID x 10 days | ||
**Peds (>8yo): | **Peds (>8yo): 40mg/kg/day in 4 doses x 10 days (max: 2g/day) | ||
*Iodoquinol | *[[Iodoquinol]] | ||
**Adults: 650mg tid x 20 days | **Adults: 650mg tid x 20 days | ||
**Peds: 30- | **Peds: 30-40mg/kg/day in 3 doses x 20 days (max: 2g/day) | ||
==Disposition== | ==Disposition== | ||
* | *Discharge in well-hydrated patient with uncomplicated disease | ||
*Admit if needing fluid hydration, fulminant balantidiasis, or any complication | *Admit if needing fluid hydration, fulminant balantidiasis, or any complication | ||
==See Also== | ==See Also== | ||
*[[ | *[[Parasitic diseases]] | ||
==External Links== | ==External Links== | ||
*[http://www.cdc.gov/parasites/balantidium/ CDC - Parasites - Balantidiasis] | |||
== | ==References== | ||
<references/> | |||
[[Category:ID]] | [[Category:ID]] |
Latest revision as of 11:48, 7 July 2017
Background
- Infection of large intestine by parasite, Balantidium coli
- Large, ciliated protozoan
- Simple life cycle: dormant cyst to trophozoite to cyst
- Reservoir host is pig (asymptomatic)
- Pig sheds feces with cysts => contaminated water and food => ingested by humans => parasite resides in large intestine
- Parasite usually resides in lumen of intestine but can also penetrate mucosa
- Opportunistic infection
- Human-to-human transmission via fecal-oral route as well
- Worldwide prevalence 0.02-1%[1] and found wherever pigs are found
- Risk factors:
- Close contact between human and pigs
- Lack of appropriate waste disposal that can contaminate drinking water sources
- Subtropical/tropical climates (warmth and humidity favor survival of cyst)
- Compromised immune system, elderly, malnourished, alcoholics
Clinical Features
- Range of mild to severe disease
- Asymptomatic hosts (usually immunocompetent)
- Chronic infection: non-bloody diarrhea, cramping, abdominal pain
- Fulminant balantidiasis: mucoid, bloody stools
- Rarely, colonic perforation
- Extra-intestinal cases are rare
- Rarely infecting lungs causing pneumonia or pulmonary hemorrhage
- Mostly seen in elderly or immunocompromised
- Death is rare
Differential Diagnosis
Evaluation
- Stool samples over several days (excretion of parasites can be erratic)
- Wet mount slide preparation: large 150-200um ovoid shape with cilia, swimming aimlessly in circles
- If suspect infection of pulmonary system, perform BAL
Management
- Metronidazole OR
- Adults: 500-750mg tid x 5 days
- Peds: 35-50mg/kg/day in 3 doses x 5 days (max: 2g/day)
- Tetracycline OR
- Adult: 500mg QID x 10 days
- Peds (>8yo): 40mg/kg/day in 4 doses x 10 days (max: 2g/day)
- Iodoquinol
- Adults: 650mg tid x 20 days
- Peds: 30-40mg/kg/day in 3 doses x 20 days (max: 2g/day)
Disposition
- Discharge in well-hydrated patient with uncomplicated disease
- Admit if needing fluid hydration, fulminant balantidiasis, or any complication
See Also
External Links
References
- ↑ Schuster FL and Ramirez-Avila L. Current World Status of Balantidium coli. Clin. Microbiol. 2008; 21(4):626–638.