Bacitracin: Difference between revisions
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*Half-life: | *Half-life: | ||
*Metabolism: | *Metabolism: | ||
*Excretion: | *Excretion: Urine 10-40% | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
Revision as of 22:34, 11 October 2017
Administration
- Type: Topical antibiotic
- Dosage Forms: ointment
- Dosage strengths: 500 unit/g
- Routes of Administration: topical, ophthalmic, IM
- Common Trade Names: BACiiM, Baciguent, Bacitracin Ophthalmic Ointment
Adult Dosing
- Apply to wound 2-5 times per day
Pediatric Dosing
- Apply to wound 2-5 times per day
- Staph pneumonia/empyema known to be susceptible to bacitracin: 900-1000 units/kg/day IM in 2 to 3 divided doses
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk minimal
- Renal: no adjustment
- Hepatic: No adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Renal toxicity (IM only)
Common
- Contact dermatitis
Pharmacology
- Half-life:
- Metabolism:
- Excretion: Urine 10-40%
Mechanism of Action
- Interferes with cell wall peptidoglycan activity
- Active against staph