Anticoagulant
|
Half-life
|
Removed by HD
|
Strategies to reverse or minimize anticoagulant effects
|
Apixaban (Eliquis®) |
8-15 hrs (longer in renal impairment) |
No |
- If ingested within 2 hours, administer activated charcoal
- 4-factor PCC (Kcentra™)^
- 25units/kg—max 2500 units for treatment of documented intracranial hemorrhage
- 50 units/kg—max 5000 units for all other life-threatening bleeds
|
Edoxaban (Savaysa®) |
10-14 hrs (longer in renal impairment) |
~ 25% |
As above
|
Rivaroxaban (Xarelto®) |
9-13 hrs (longer in renal impairment) |
No |
As above
|
Fondaparinux (Arixtra®) |
17-21 hrs (significantly longer in renal impairment) |
No |
4-factor PCC (Kcentra™)^ 50 units/kg—max 5000 units
|