The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Table
| Class
|
Known as
|
Examples
|
Mechanism
|
Clinical uses
|
| Ia
|
fast-channel blockers-Affect QRS complex
|
|
(Na+) channel block (intermediate association/dissociation)
|
- Ventricular arrhythmias
- prevention of paroxysmal Recurrent atrial fibrillation (triggered by Vagus nerve overactivity)
- procainamide in Wolf Parkinson White (WPW)
|
| Ib- Do not affect QRS complex
|
|
|
(Na+) channel block (fast association/dissociation)
|
- treatment and prevention during and immediately after Myocardial infarction, though this practice is now discouraged given the increased risk of Asystole
- Ventricular tachycardia
- Atrial fibrillation
|
| Ic
|
|
|
(Na+) channel block (slow association/dissociation)
|
- prevents Paroxysmal atrial fibrillation
- treats Recurrent tachyarrhythmias of abnormal conduction system.
- contraindicated immediately post-myocardial infarction.
|
| II
|
Beta-blockers
|
|
beta blocking
Propranolol also shows some class I action
|
- decrease Myocardial infarction mortality
- prevent recurrence of Tachyarrhythmias
|
| III
|
|
|
K+ channel blocker
Sotalol is also a β-blocker
Amiodarone has Class I, II, and III activity
|
|
| IV
|
slow-channel blockers
|
|
Ca2+ channel blocker
|
- prevent recurrence of Paroxysmal supraventricular tachycardia
- reduce Ventricular rate in patients with Atrial fibrillation
|
| V
|
|
|
Work by other or unknown mechanisms (Direct nodal inhibition).
|
Used in supraventricular arrhythmias,
Or in the case of magnesium sulfate, used in torsade de pointes.
|
See Also
References
- Katzung & Trevor's Pharmacology
