Ankylosing spondylitis: Difference between revisions

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==Background==
==Background==
*Ankylosing spondylitis (AS) is a chronic inflammatory disease of the axial skeleton with variable involvement of other joints or even nonarticular structures.
*Ankylosing spondylitis (AS) is a chronic inflammatory disease of the axial skeleton with variable involvement of other joints or even nonarticular structures
* Ankylosing spondylitis is three times more common in males than females. It is usually diagnosed in young adults between the ages of 20 and 30 years.
*3x more common in males than females
* Often associated with other autoimmune disorders. About 90% of people with AS express the HLA-B27 genotype.
*Typically diagnosed in young adults between the ages of 20 and 30 yrs
*Often associated with other autoimmune disorders
*90% of people with AS express the HLA-B27 genotype
*[[Uveitis]] is common extra-articular manifestation, seen in 30% of patients


==Clinical Features==
==Clinical Features==
* Spinal pain, particularly in the lower back, is usually the first and most common symptom of AS.
*[[back pain|Spinal pain]], particularly in the lower back, is usually the first and most common symptom of AS
**Begins in early adulthood (before 45 years of age)
**Begins in early adulthood (before 45 yrs)
**Has a gradual onset
**Has a gradual onset
**Lasts longer than three months
**Lasts longer than three months
**Is worse after rest (for example, in the morning) but improves with activity
**Is worse after rest (for example, in the morning) but improves with activity
**Can cause morning stiffness lasting more than 30 minutes
**Can cause morning stiffness lasting more than 30 minutes
* Fatigue
*Fatigue
* Can also be associated with anterior uvetitis, bowel ulcers and spinal fractures are 4 times more common in patients with AS  
*Can also be associated with anterior [[uveitis]], [[arthritis]], [[psoriasis]], enthesitis, [[IBD]] and [[spine fractures]] (4 times more common in patients with AS <ref> Westerveld LA, Verlaan JJ, Oner FC. Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications. European Spine Journal. 2009;18(2):145–156 </ref>)


==Differential Diagnosis==
==Differential Diagnosis==
{{Lower back pain DDX}}
{{Lower back pain DDX}}
==Diagnosis==
 
==Evaluation==
*There is no direct test for AS
*There is no direct test for AS
* ESR, CRP can be elevated but not sensitive or specific for AS
*ESR, CRP can be elevated but not sensitive or specific
* Xray lumbar/sacroiliac: The earliest changes in the sacroiliac joints shows erosions and sclerosis.
*Xray lumbar/sacroiliac: The earliest changes in the sacroiliac joints shows erosions and sclerosis
**Progression of the erosions leads to pseudo widening of the joint space and bony ankylosis AKA "Bamboo Spine." Often X-ray findings lag about 10 years from initial progression of disease. [[File:5269907670e86d9b415221efa30bf166.jpg|200px|thumb|right|"bamboo spine"]]
**Progression of erosions leads to pseudo widening of the joint space and bony ankylosis AKA "Bamboo Spine"  
* CBC
Often X-ray findings lag about 10 years from initial progression of disease [[File:5269907670e86d9b415221efa30bf166.jpg|200px|thumb|right|"bamboo spine"]]
*CBC
*Chem 10
*Chem 10
* UA
*[[Urinalysis]]
* Genetic testing for HLA B27 ( > 90% of people with AS have this gene, though by it's self is not specific)
*Genetic testing for HLA B27 ( > 90% of people with AS have this gene, though by itself is not specific)
 
==Management==
==Management==
*There is no cure for AS, although treatments and medications can reduce symptoms and pain
*There is no cure for AS, although treatments (e.g. exercise, posture training) and medications can reduce symptoms and pain
* Exercise and posture training should be part of the treatment program for everyone with AS
*[[NSAIDS]]
* NSAIDS
*[[Sulfasalazine]] can be used in people with peripheral arthritis, but for axial involvement, evidence does not support it <ref>Chen J, Lin S, Liu C. Sulfasalazine for ankylosing spondylitis. Cochrane Database of Systematic Reviews 2014, Issue 11. Art. No.: CD004800. DOI: 10.1002/14651858.CD004800.pub3.</ref>.  
* Sulfasalazine can be used in people with peripheral arthritis. For axial involvement, evidence does not support sulfasalazine <ref>Chen J, Lin S, Liu C. Sulfasalazine for ankylosing spondylitis. Cochrane Database of Systematic Reviews 2014, Issue 11. Art. No.: CD004800. DOI: 10.1002/14651858.CD004800.pub3.</ref>. Lack of evidence for methotrexate <ref>Chen J, Veras MMS, Liu C, Lin J. Methotrexate for ankylosing spondylitis. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD004524. DOI: 10.1002/14651858.CD004524.pub4.</ref> or steroids.  
*Lack of evidence for methotrexate <ref>Chen J, Veras MMS, Liu C, Lin J. Methotrexate for ankylosing spondylitis. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD004524. DOI: 10.1002/14651858.CD004524.pub4.</ref> or steroids.  
* Tumor necrosis factor-alpha blockers, such as the biologics etanercept, infliximab, golimumab and adalimumab, have shown good short-term effectiveness in the form of profound and sustained reduction in all clinical and laboratory measures of disease activity. Though long term management is currently being studied.
*Tumor necrosis factor-alpha blockers, such as the biologics etanercept, infliximab, golimumab and adalimumab, provide good short-term effectiveness though long term management is currently being studied
 
==Disposition==
==Disposition==
* Often diagnosis will not be made in ER but if made in ER often can be discharged home with PMD F/U or Close Rheumatology f/u
*Often diagnosis will not be made in ED but if made in ED often can be discharged home with primary care follow up or rheumatology follow up
 
==See Also==
==See Also==
*[[Arthritis]]


==External Links==
==External Links==
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==References==
==References==
<references/>
<references/>
[[Category:Rheumatology]]

Latest revision as of 15:44, 10 February 2021

Background

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease of the axial skeleton with variable involvement of other joints or even nonarticular structures
  • 3x more common in males than females
  • Typically diagnosed in young adults between the ages of 20 and 30 yrs
  • Often associated with other autoimmune disorders
  • 90% of people with AS express the HLA-B27 genotype
  • Uveitis is common extra-articular manifestation, seen in 30% of patients

Clinical Features

  • Spinal pain, particularly in the lower back, is usually the first and most common symptom of AS
    • Begins in early adulthood (before 45 yrs)
    • Has a gradual onset
    • Lasts longer than three months
    • Is worse after rest (for example, in the morning) but improves with activity
    • Can cause morning stiffness lasting more than 30 minutes
  • Fatigue
  • Can also be associated with anterior uveitis, arthritis, psoriasis, enthesitis, IBD and spine fractures (4 times more common in patients with AS [1])

Differential Diagnosis

Lower Back Pain

Evaluation

  • There is no direct test for AS
  • ESR, CRP can be elevated but not sensitive or specific
  • Xray lumbar/sacroiliac: The earliest changes in the sacroiliac joints shows erosions and sclerosis
    • Progression of erosions leads to pseudo widening of the joint space and bony ankylosis AKA "Bamboo Spine"

Often X-ray findings lag about 10 years from initial progression of disease

"bamboo spine"
  • CBC
  • Chem 10
  • Urinalysis
  • Genetic testing for HLA B27 ( > 90% of people with AS have this gene, though by itself is not specific)

Management

  • There is no cure for AS, although treatments (e.g. exercise, posture training) and medications can reduce symptoms and pain
  • NSAIDS
  • Sulfasalazine can be used in people with peripheral arthritis, but for axial involvement, evidence does not support it [2].
  • Lack of evidence for methotrexate [3] or steroids.
  • Tumor necrosis factor-alpha blockers, such as the biologics etanercept, infliximab, golimumab and adalimumab, provide good short-term effectiveness though long term management is currently being studied

Disposition

  • Often diagnosis will not be made in ED but if made in ED often can be discharged home with primary care follow up or rheumatology follow up

See Also

External Links

References

  1. Westerveld LA, Verlaan JJ, Oner FC. Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications. European Spine Journal. 2009;18(2):145–156
  2. Chen J, Lin S, Liu C. Sulfasalazine for ankylosing spondylitis. Cochrane Database of Systematic Reviews 2014, Issue 11. Art. No.: CD004800. DOI: 10.1002/14651858.CD004800.pub3.
  3. Chen J, Veras MMS, Liu C, Lin J. Methotrexate for ankylosing spondylitis. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD004524. DOI: 10.1002/14651858.CD004524.pub4.