Amphetamines: Difference between revisions
No edit summary |
(Updated background) |
||
Line 1: | Line 1: | ||
[[File:Amphetamine.png|thumbnail|Amphetamine]] | |||
[[File:MDMA.png|thumbnail|MDMA]] | |||
[[File:Mescaline.png|thumbnail|Mescaline]] | |||
==Background== | ==Background== | ||
*Class of xenobiotics (Substituted amphetamines) based on a common central structure (ethylamine group attached to a phenol ring) | |||
**All have mixed serotonergic and dopaminergic activity | |||
*Unlike cocaine, duration of action may be 12hr or longer | *Unlike cocaine, duration of action may be 12hr or longer | ||
**Time- oral- 30min, inhaled instant | |||
**hepatic and renal excretion- lasts 6- 24 hrs | |||
**if tolerance developes- physical exam may yield normal findings | |||
**desipramine and amantadine can give false positive for urine amphet test | |||
**hallucinogenic amphetamine derivatives may not show up on tox screen AKA Entactogens- enabling user to touch within | |||
===Methamphetamine=== | ===Methamphetamine=== | ||
Line 43: | Line 44: | ||
==See Also== | ==See Also== | ||
[[Toxidromes]] | [[Toxidromes]] | ||
PiKHAL: A Chemical Love Story by Alexander Schulgin | |||
==Source== | ==Source== |
Revision as of 16:51, 8 January 2014
Background
- Class of xenobiotics (Substituted amphetamines) based on a common central structure (ethylamine group attached to a phenol ring)
- All have mixed serotonergic and dopaminergic activity
- Unlike cocaine, duration of action may be 12hr or longer
- Time- oral- 30min, inhaled instant
- hepatic and renal excretion- lasts 6- 24 hrs
- if tolerance developes- physical exam may yield normal findings
- desipramine and amantadine can give false positive for urine amphet test
- hallucinogenic amphetamine derivatives may not show up on tox screen AKA Entactogens- enabling user to touch within
Methamphetamine
- More combative
- Delusions of parasites, formication, self-mutilate
- more dysphoric
MDMA Ecstacy
- Increases serotonin, dopamine
- Lasts 3 - 5hrs
- Hyponatremia
Diagnosis
Alpha
- pupils dilate
- sweat
- decrease gi peristalsis
- constrict blood vessels
Beta
- inc HR and contractility
- dilate bronchi
- dilate muscle beds
Mixed
- delusions, paranoia, aggression, poor judgement, hallucinate, confusion
Treatment
- Benzos
See Also
Toxidromes PiKHAL: A Chemical Love Story by Alexander Schulgin
Source
MISTRY 6/06