Amphetamines: Difference between revisions

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[[File:Amphetamine.png|thumbnail|Amphetamine]]
[[File:MDMA.png|thumbnail|MDMA]]
[[File:Mescaline.png|thumbnail|Mescaline]]
==Background==
==Background==
*Class of xenobiotics (Substituted amphetamines) based on a common central structure (ethylamine group attached to a phenol ring)
**All have mixed serotonergic and dopaminergic activity
*Unlike cocaine, duration of action may be 12hr or longer
*Unlike cocaine, duration of action may be 12hr or longer
 
**Time- oral- 30min, inhaled instant
- Time- oral- 30min, inhaled instant
**hepatic and renal excretion- lasts 6- 24 hrs
 
**if tolerance developes- physical exam may yield normal findings
- hepatic and renal excretion- lasts 6- 24 hrs
**desipramine and amantadine can give false positive for urine amphet test
 
**hallucinogenic amphetamine derivatives may not show up on tox screen AKA Entactogens- enabling user to touch within
- if tolerance developes- physical exam may yield normal findings
 
- desipramine and amantadine can give false positive for urine amphet test
 
- hallucinogenic amphet deriv may not show up on tox screen AKA Entactogens- enabling user to touch within


===Methamphetamine===
===Methamphetamine===
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==See Also==
==See Also==
[[Toxidromes]]
[[Toxidromes]]
PiKHAL: A Chemical Love Story by Alexander Schulgin


==Source==
==Source==

Revision as of 16:51, 8 January 2014

Amphetamine
MDMA
Mescaline

Background

  • Class of xenobiotics (Substituted amphetamines) based on a common central structure (ethylamine group attached to a phenol ring)
    • All have mixed serotonergic and dopaminergic activity
  • Unlike cocaine, duration of action may be 12hr or longer
    • Time- oral- 30min, inhaled instant
    • hepatic and renal excretion- lasts 6- 24 hrs
    • if tolerance developes- physical exam may yield normal findings
    • desipramine and amantadine can give false positive for urine amphet test
    • hallucinogenic amphetamine derivatives may not show up on tox screen AKA Entactogens- enabling user to touch within

Methamphetamine

  • More combative
  • Delusions of parasites, formication, self-mutilate
  • more dysphoric

MDMA Ecstacy

  • Increases serotonin, dopamine
  • Lasts 3 - 5hrs
  • Hyponatremia

Diagnosis

Alpha

  • pupils dilate
  • sweat
  • decrease gi peristalsis
  • constrict blood vessels

Beta

  • inc HR and contractility
  • dilate bronchi
  • dilate muscle beds

Mixed

  • delusions, paranoia, aggression, poor judgement, hallucinate, confusion

Treatment

  • Benzos

See Also

Toxidromes PiKHAL: A Chemical Love Story by Alexander Schulgin

Source

MISTRY 6/06