Difference between revisions of "Aluminum toxicity"

 
Line 12: Line 12:
 
==Aluminum oxide==
 
==Aluminum oxide==
 
*Physical irritant, nuisance particulate
 
*Physical irritant, nuisance particulate
 +
 +
==Systemic aluminum toxicity===
 +
*Usually in renal patients on long-term dialysis with aluminum-containing dialysate
 +
*Rarely acute
 +
*Muscle weakness (especially proximal)
 +
*Premature osteoporosis, bone pain, multiple fractures
 +
*Seziures
 +
*Acute or subacute [[altered mental status]]
  
 
==Evaluation==
 
==Evaluation==
 +
*Aluminum level > 50 µg/L (mcg/dL) suggests aluminum overload and possible toxicity
 +
**Symptomatic patients with levels 20-50 may also need treatment
  
 
==Management==
 
==Management==
 +
*Stop exposure
 +
*Chelation with [[deferoxamine]] for severe or symptomatic systemic toxicity
  
 
==Disposition==
 
==Disposition==

Latest revision as of 15:16, 22 August 2017

Aluminum Metal

  • Dusts cause respiratory tract and eye irritation
  • Acute exposures can cause bronchoconstriction and asthma-like response
  • Chronic exposure can lead to pulmonary fibrosis
  • Increased incidence of cancer

Aluminum phosphide

  • Used as a fumigant
  • Contact with moisture produces phosphine gas
  • Respiratory tract irritant

Aluminum oxide

  • Physical irritant, nuisance particulate

Systemic aluminum toxicity=

  • Usually in renal patients on long-term dialysis with aluminum-containing dialysate
  • Rarely acute
  • Muscle weakness (especially proximal)
  • Premature osteoporosis, bone pain, multiple fractures
  • Seziures
  • Acute or subacute altered mental status

Evaluation

  • Aluminum level > 50 µg/L (mcg/dL) suggests aluminum overload and possible toxicity
    • Symptomatic patients with levels 20-50 may also need treatment

Management

  • Stop exposure
  • Chelation with deferoxamine for severe or symptomatic systemic toxicity

Disposition

See Also

External Links

References