African trypanosomiasis

Revision as of 18:13, 27 March 2017 by ClaireLewis (talk | contribs)


  • AKA sleeping sickness
  • Caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense
  • Transmitted by the tsetse fly

Clinical Features

  • initial features
    • Localized inflammatory reaction after tsetse fly bite
    • Painless chancre 2-3 days later, lasts 2-3 weeks
  • Systemic disease
    • Intermittent Fever
    • Malaise, wasting
  • CNS involvement
  • Other complications
  • Winterbottom's sign: posterior cervical LAD (Gambiense)

Differential Diagnosis

Travel-related skin conditions

See also domestic U.S. ectoparasites


  • Blood smear to identify parasite
  • Parasites can also be found in lymph nodes, chancres, bone marrow, or CSF


  • Consult ID early!
  • No CNS involvement
  • CNS involvement
    • Melarsoprol, eflornithine, or a combination of nifurtimox and eflornithine


See Also

External Links