Acute myeloid leukemia: Difference between revisions

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==Differential Diagnosis==
==Differential Diagnosis==
{{Leuk/lymph DDX}}


==Diagnosis==
==Diagnosis==

Revision as of 19:54, 11 May 2015

Background

  • aka Acute myelogenous leukemia or non-lymphocytic leukemia
  • Most common acute leukemia in adults (around 80% of cases)
  • 65yo median age of diagnosis, Male:Female 5:3
  • characterized by clonal proliferation of myeloid precursors(blast cells >20% in the periphery)

Clinical Features

  • Presents with anemia, neutropenia, thrombocytopenia,
  • weakness, easy fatigability, infections, gingival bleeding/enlargement, ecchymoses, epistaxis, menorrhagia

Differential Diagnosis

Acute Leukemia/Lymphoma

Diagnosis

  • CXR
  • CBC with peripheral smear
  • Chem7, ca, mg, phos, Uric Acid, UA, LDH (to check for Tumor Lysis)
  • LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen (to check for DIC)
  • Get extra purple top for flow cytometry, especially before transfusion

Treatment

See Also

References