Difference between revisions of "Acute generalized exanthematous pustulosis"

(Differential Diagnosis)
(Differential Diagnosis)
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==Differential Diagnosis==
 
==Differential Diagnosis==
 
*[[Erythema Multiforme]]
 
*[[Erythema Multiforme]]
*[[Drug rash]]
 
  
 
{{Erythematous rash DDX}}
 
{{Erythematous rash DDX}}

Revision as of 02:31, 27 November 2019

Background

  • T-cell mediated rash with systemic features
  • >90% of cases attributable to a medication (usually an antibiotic)
  • Mortality rate of ~5%

Clinical Features

Acute generalized exanthematous pustulosis
  • Onset 1-5 days after starting causative medication
  • Rash:
    • Large areas of edematous erythema with numerous small, non-follicular pustules
    • Predominantly affects main body folds and upper trunk, but can involve face
    • NO mucous membrane involvement (in contrast to SJS/TEN)
  • Systemic findings:

Differential Diagnosis

Erythematous rash

Evaluation

  • Clinical diagnosis
  • CBC
  • BMP
  • LFTs

Management

  • Stop inciting agent
  • IVF- treat similar to fluid resuscitation in burns
  • Wound care, infection control

Disposition

  • Admit

See Also

External Links

References