Difference between revisions of "Acute generalized exanthematous pustulosis"
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==Clinical Features== | ==Clinical Features== | ||
| − | [[File:Acute generalized exanthematous pustulosis.png|thumb|]] | + | [[File:Acute generalized exanthematous pustulosis.png|thumb|Acute generalized exanthematous pustulosis]] |
*Onset 1-5 days after starting causative medication | *Onset 1-5 days after starting causative medication | ||
*[[Rash]]: | *[[Rash]]: | ||
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==See Also== | ==See Also== | ||
| + | *[[Erythematous rash]] | ||
*[[Stevens-Johnson syndrome and toxic epidermal necrolysis]] | *[[Stevens-Johnson syndrome and toxic epidermal necrolysis]] | ||
*[[DRESS syndrome]] | *[[DRESS syndrome]] | ||
Revision as of 01:27, 27 November 2019
Contents
Background
- T-cell mediated rash with systemic features
- >90% of cases attributable to a medication (usually an antibiotic)
- Mortality rate of ~5%
Clinical Features
- Onset 1-5 days after starting causative medication
- Rash:
- Large areas of edematous erythema with numerous small, non-follicular pustules
- Predominantly affects main body folds and upper trunk, but can involve face
- NO mucous membrane involvement (in contrast to SJS/TEN)
- Systemic findings:
- Fever
- Leukocytosis, specifically neutrophilia
- +/- Facial swelling
- +/- Hepatitis
- +/- Eosinophilia
Differential Diagnosis
- Erythema Multiforme
- Stevens-Johnson syndrome and toxic epidermal necrolysis
- Staphylococcal scalded skin syndrome
- Erythroderma
- Toxic Shock Syndrome
- Drug rash
- DRESS syndrome
Evaluation
- Clinical diagnosis
- CBC
- BMP
- LFTs
Management
- Stop inciting agent
- IVF- treat similar to fluid resuscitation in burns
- Wound care, infection control
Disposition
- Admit