Difference between revisions of "Acute generalized exanthematous pustulosis"

(Created page with "==Background== *T-cell mediated rash with systemic features *>90% of cases attributable to a medication (usually an antibiotic) *Mortality rate of ~5% ==Clinical Features...")
 
(Clinical Features)
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[[File:Acute generalized exanthematous pustulosis.png|thumb|]]
 
[[File:Acute generalized exanthematous pustulosis.png|thumb|]]
 
*Onset 1-5 days after starting causative medication
 
*Onset 1-5 days after starting causative medication
*Rash:
+
*[[Rash]]:
 
**Large areas of edematous erythema with numerous small, non-follicular pustules
 
**Large areas of edematous erythema with numerous small, non-follicular pustules
 
**Predominantly affects main body folds and upper trunk, but can involve face
 
**Predominantly affects main body folds and upper trunk, but can involve face
**NO mucous membrane involvement
+
**NO mucous membrane involvement (in contrast to SJS/TEN)
 
*Systemic findings:
 
*Systemic findings:
**Fever
+
**[[Fever]]
**Neutrophilia
+
**[[Leukocytosis]], specifically neutrophilia
 
**+/- Facial swelling
 
**+/- Facial swelling
**+/- Hepatitis
+
**+/- [[Hepatitis]]
**+/- Eosinophilia
+
**+/- [[Eosinophilia]]
 
 
  
 
==Differential Diagnosis==
 
==Differential Diagnosis==

Revision as of 05:06, 11 December 2016

Background

  • T-cell mediated rash with systemic features
  • >90% of cases attributable to a medication (usually an antibiotic)
  • Mortality rate of ~5%

Clinical Features

Acute generalized exanthematous pustulosis.png
  • Onset 1-5 days after starting causative medication
  • Rash:
    • Large areas of edematous erythema with numerous small, non-follicular pustules
    • Predominantly affects main body folds and upper trunk, but can involve face
    • NO mucous membrane involvement (in contrast to SJS/TEN)
  • Systemic findings:

Differential Diagnosis

Evaluation

  • Clinical diagnosis
  • CBC
  • BMP
  • LFTs

Management

  • Stop inciting agent
  • IVF- treat similar to fluid resuscitation in burns
  • Wound care, infection control

Disposition

  • Admit

See Also

External Links

References