Acebutolol

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Administration

  • Type: Beta blocker
  • Dosage Forms: Cap: 200mg, 400mg
  • Routes of Administration: Oral
  • Common Trade Names: Sectral

Adult Dosing

Hypertension

  • 400-800 mg PO bid
    • Max: 1200 mg/day (800mg in elderly pts)

Ventricular arrhythmia

  • 300-600 mg PO bid
    • Max: 1200 mg/day (800mg in elderly pts)

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

  • Pregnancy Rating: Possible risk of intrauterine growth restriction
  • Lactation risk: Avoid during breastfeeding

Renal Dosing

  • Adult:
    • CrCl 25-50: Decrease dose 50%
    • CrCl <25: Decrease dose 75%
    • HD/PD: No supplement
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Caution advised
  • Pediatric: Not defined

Contraindications

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 3-4 hours (8-13h diacetolol)
  • Metabolism: Liver; Production of active metabolite (diacetolol)
  • Excretion: Bile/feces/gut wall 50-60%; Urine 30-40% (12-29% unchanged)

Mechanism of Action

  • Selectively antagonizes beta-1 adrenergic receptors
  • Class II antiarrhythmic

Comments

See Also

References