AIDS fever of unknown origin
Background
- Sources of fever vary by stage of disease:
- CD4 >500
- Work-up similarly to nonimmunocompromised pts
- CD4 200-500
- Early bacterial respiratory infection most common
- CD4 <200
- PCP, central line infection, MAC, TB, CMV, drug fever, sinusitis
- Also consider: endocarditis, lymphoma, histo, crypto
- CD4 <100
- Consider disseminated MAC
- Toxoplasmosis (CNS or pulmonary)
- CD4 >500
Workup
- CBC
- Chemistry
- LFT
- LDH
- RPR
- UA/Cx
- Blood cx
- Aerobic, anaerobic, fungal
- Crypto
- Toxo
- Coccidiodomycosis
- CXR
- Stool cx / O&P
- CT
- LP
- Cell count, protein, glucose, VDRL, cryptocoocal antigen, cytology, toxo, CMV, JC, EBV
See Also
Source
Tintinalli