ACTH (cosyntropin) stimulation test: Difference between revisions
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*Adrenal Insufficiency: Cortisol level fails to rise after Cosyntropin administration | *Adrenal Insufficiency: Cortisol level fails to rise after Cosyntropin administration | ||
== Treatment== | ==Treatment== | ||
*Then give either | *Then give either | ||
**[[Dexamethasone]] 6mg IV | **[[Dexamethasone]] 6mg IV |
Revision as of 18:01, 6 July 2016
Background
- ACTH (cosyntropin) stimulation test measures how well the adrenal glands respond to adrenocorticotropic hormone (ACTH)
- ACTH is a hormone produced in the pituitary gland that stimulates the adrenal glands to release a hormone called cortisol
- Man-made form of ACTH is called cosyntropin
Test
- Before: Draw serum cortisol
- Time 0: Give ^0.25mg IM/IV of ACTH (Cosyntropin) over 2min
- Time 30: Draw serum cortisol
- Time 60: Draw serum cortisol & give 100mg hydrodortison IVP
^0.125mg if <2yrs old
- Normal Response: Cortisol level doubles from baseline after Cosyntropin administration
- Adrenal Insufficiency: Cortisol level fails to rise after Cosyntropin administration
Treatment
- Then give either
- Dexamethasone 6mg IV
- OR
- Hydrocortisone 100mg IV