Cyclobenzaprine

Administration

• Type: muscle relaxant
• Dosage Forms:
• Routes of Administration: Oral
• Common Trade Names: Flexeril

Adult Dosing

• 5-10mg PO 1-3 times per day

Special Populations

• Pregnancy Rating: B
• Lactation risk: infant risk cannot be ruled out

Renal Dosing

• Adult:
• Pediatric:

Hepatic Dosing

• Adult: Titrate slowly
• Pediatric:

Contraindications

• Allergy to class/drug
• MAOI use, concomitantly or within 14 days
• Heart block or other serious arrhythmias, CHF

Adverse Reactions

Serious

• Neuroleptic malignant syndrome
• Serotonin syndrome
• Stroke
• Dysrhythmias, heart block
• Bone marrow depression
• Hepatitis

Common

• Somnolence, dizziness
• Nausea, constipation

Pharmacology

• Half-life: ~18h for immediate release, 32h for extended release
• Metabolism: hepatic
• Excretion:

Mechanism of Action

• Acts on CNS to reduce tonic somatic motor activity