Prostaglandin E1
General
- Type: smooth muscle relaxer, vasodilator
- Dosage Forms:
- Common Trade Names: Alprostadil; Prostin VR
Adult Dosing
Pediatric Dosing[1]
- Start infusion at 0.05 mcg/kg/min IV
- Titrate to 0.1 mcg/kg/min as tolerated, monitoring for hypotension (and apnea)
Special Populations
- Pregnancy Rating: C
- Lactation: infant risk cannot be ruled out
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- Hypotension
- Bradycardia
- Seizures
- Apnea
Pharmacology
- Half-life: 5-10m
- Metabolism: Lung
- Excretion: Renal
- Mechanism of Action: synthetic of endogenous prostaglandin
Comments
- Cyanotic neonates with ductal-dependent lesions typically respond within 10-15 minutes, but may not show response until several hours after the start of infusion.
See Also
References
- ↑ Donofrio MT, Moon-Grady AJ, Hornberger LK, Copel JA, Sklansky MS, Abuhamad A, Cuneo BF, Huhta JC, Jonas RA, Krishnan A, Lacey S, Lee W, Michelfelder EC Sr, Rempel GR, Silverman NH, Spray TL, Strasburger JF, Tworetzky W, Rychik J. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. American Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in the Young and Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Council on Cardiovascular and Stroke Nursing.Circulation. 2014 May 27;129(21):2183-242. doi: 10.1161/01.cir.0000437597.44550.5d. Epub 2014 Apr 24.