Amiodarone

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Adult Dosing

  • V-fib/pulseless V-tach
    • Loading dose = 300mg IV bolus followed by 150mg bolus prn
  • Stable V-tach or SVT
    • Loading dose = 150mg IV in 100mL D5W over 10min
      • Follow by infusion of 1mg/min x 6hr; 0.5mg/min thereafter

Contraindications

  • Iodine or shellfish allergy
  • Pregnancy

Indications

  • Ventricular and supraventricular arrhythmias
  • 1st line for pulseless V-tach/V-fib
  • Used for atrial arrhythmias in pts w/ decr EF

Mechanism of Action

  • Class III - Inhibits potassium channels
    • Impairs SA and AV node conduction
    • Decreases automaticity
    • Prolongs refractory period in accessory pathways
  • Also has class I & II properties

Adverse Drug Rxns

  • Bradycardia, hypotension
  • Prolonged QT

See Also

Antiarrhythmics

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