Oxcarbazepine

Administration

• Type: anti epileptic
• Dosage Forms: 150,300,600; 300/5 mL
• Routes of Administration: PO
• Common Trade Names: Trileptal

Adult Dosing

Partial seizures

• adjunct tx: Dose: 600 mg PO bid; Start: 300 mg PO bid, incr. by up to 600 mg/day qwk; Max: 2400 mg/day;
• conversion to monotherapy: Dose: 1200 mg PO bid; Start: 300 mg PO bid, incr. by up to 600 mg/day qwk; Max: 2400 mg/day; D/C concomitant anticonvulsants over 3-6wk; taper dose gradually to D/C
• initial monotherapy: Dose: 600 mg PO bid; Start: 300 mg PO bid, incr. by 300 mg/day q3 days; Max: 2400 mg/day

Trigeminal neuralgia

• 450-1200 mg PO bid
• Start: 300 mg PO bid, may incr. by 600 mg/day qwk

Bipolar disorder

• 600-1200 mg PO bid
• Start: 300 mg PO bid, incr. by 300 mg/day q3 days or by 600 mg/day qwk

Special Populations

• Pregnancy Rating:
• Lactation risk:

Renal Dosing

• Adult: CrCl <30: start 150 mg bid; HD/PD: no supplement; Info: titrate dose slowly until response
• Pediatric:

Hepatic Dosing

• Adult: mild-mod impairment: no adjustment; severe impairment: not defined
• Pediatric:

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion: