Intralipid

General

• Type: Lipid emulsion
• Dosage Forms: 20% fat emulsion
• Routes of Administration: IV
• Common Trade Names: Intralipid
• Emergency department indications: Local anesthetic systemic toxicity, refractory hemodynamic instability 2/2 ingestion of cardiodepressive medications / toxins (i.e. Beta blocker or Calcium Channel Blocker)

Adult Dosing

• 1.5 ml/kg bolus
  • Followed by 0.25 ml/kg/min for 20 min or until hemodynamic stability is achieved.

Special Populations

• Pregnancy Rating: C
• Lactation risk:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Pancreatitis

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

See Also

• Beta-blocker toxicity
• Calcium channel blocker toxicity
• Local Anesthetic Systemic Toxicity (LAST)

External Links

• LipidRescue