Template:Thrombocytopenia

Decreased production

• Marrow infiltration (tumor or infection)
• Viral infections (rubella, HIV)

Drugs

• Heparin-Induced Thrombocytopenia (HIT)
  • sulfa antibiotics, ETOH, ASA, thiazides/furosemide
• Radiation
• Vitamin B12 and/or folate deficiency

Increased platelet destruction

• Idiopathic thrombocytopenic purpura
• Thrombotic Thrombocytopenic Purpura (TTP)
• Hemolytic Uremic Syndrome (HUS)
• Disseminated Intravascular Coagulation (DIC)
• Viral infections (HIV, mumps, varicella, EBV)
• Drugs (heparin, protamine)

Platelet loss

• Excessive hemorrhage
• Hemodialysis, extracorporeal circulation

Splenic sequestration

• Sickle cell disease, cirrhosis