Graft-vs-host disease

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Background

  • Acute vs Chronic
    • Acute: 1-12 weeks post graft
    • Chronic: >12 weeks
  • Transplanted graft with immunologically competent cells stimulated by host antigens and host is incapable of mounting an effective immunologic response
  • Occurs in leukemia/lymphoma or immunocompromised

Clinical Features

Differential Diagnosis

Diagnosis

  • LFT abnormalities
  • Pancytopenia

Management

  • Glucocorticoids

Disposition

See Also

External Links

References