Ecallantide

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General

  • Type: Kallikrein inhibitor for angioedema
  • Dosage Forms: 30mg
  • Routes of Administration: SQ
  • Common Trade Names: Kalbitor

Adult Dosing

  • 30mg SQ
  • Max 60mg/ 24 hr

Pediatric Dosing

  • acute hereditary angioedema >12yo
    • 30mg SQ

Special Populations

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • anaphylaxis
  • hypersensitivity reaction

Common

  • headache
  • nausea
  • fatigue
  • diarrhea
  • URI
  • injection site rxn
  • nasopharyngitis
  • vomiting
  • pruritus
  • abdominal pain
  • fever
  • anaphylaxis

Pharmacology

  • Half-life: 2h
  • Metabolism: CYP450
  • Excretion: Urine
  • Mechanism of Action: selectively, reversibly inhibits plasma kallikrein, preventing bradykinin generation

Comments

  • Plasma kallikrein works as cofactor to formation of bradykinin which is implicated in angioedema

See Also

References

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