Vitamin K

Disambiguation: See ketamine for street name "vitamin K"

General

• Type: Vitamin
• Dosage Forms: IV, IM, SC, PO
• Common Trade Names: Generic and Mephyton, K1-1000, Novaplus Vitamin K1

Pediatric Dosing

• Neonatal deficiency (hemorrhagic disease of the newborn): 1mg vitamin K SC for avoidance of anaphylaxis (IV), hematoma (IM). FFP for serious cases.

Special Populations

• Pregnancy Rating: C
• Lactation risk: Safe
• Renal Dosing
  • Adult: not defined
  • Pediatric: not defined
• Hepatic Dosing
  • Adult: adjust dose amount
  • Pediatric: adjust dose amount

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• anticoagulant resistance
• hypersensitivity rxn, severe or life-threatening (SC, IM, or IV use)
• anaphylaxis (SC, IM, or IV use)
• hyperbilirubinemia (neonates)
• hemolytic anemia (neonates)

Pharmacology

• Half-life: unknown
• Metabolism: liver, CYP450: unknown
• Excretion: urine, bile
• Mechanism of Action: Used by liver for synthesis of some coagulation factors (II,VII,IX,X,C,S). Timing in the synthesis of these factors impacts reversal of elevated INR (~4 hours: F-VII, ~24 hours: F-II). [Various: Lange Clinical. Tintinalli]