Hydrocortisone topical

General

  • Type: Topical steroid
  • Dosage Forms: 0.5%, 1%, 2.5% crm, lotion, oint
  • Common Trade Names: Cortizone, Cortaid, Hytone, Texacort

Adult Dosing

dermatoses, steroid-responsive: apply bid-qid

Pediatric Dosing

dermatoses, steroid-responsive: apply bid-qid

Special Populations

  • Pregnancy Rating: C
  • Lactation: Probably safe
  • Renal Dosing
    • Adult: none
    • Pediatric: none
  • Hepatic Dosing
    • Adult: none
    • Pediatric: none

Contraindications

  • Allergy to class/drug
  • caution if skin infection
  • caution in pediatric pts

Adverse Reactions

Serious

  • HPA axis suppresion
  • Cushing syndrome
  • hyperglycemia
  • intracranial HTN (peds pts)

Common

  • burning
  • pruritus
  • irritation
  • dryness
  • folliculitis
  • hypertrichosis
  • acneiform dermatitis
  • hypopigmentation
  • perioral dermatitis
  • allergic contact dermatitis
  • maceration
  • secondary infection
  • skin atrophy
  • striae
  • miliaria

Pharmacology

  • Half-life: 8-12h
  • Metabolism: liver primarily; CYP450
  • Excretion: urine
  • Mechanism of Action: exact mechanim of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple gluocorticoid and mineralocorticoid effects

See Also

Sources

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