Albuterol

General

• Type: Beta-2 agonist
• Dosage Forms: aerosol inhaler, liquid nebulized form, PO
• Common Trade Names: ProAir HFA, Proventil, Ventolin HFA, ReliOn Ventolin HFA, Accuneb

Special Populations

• Pregnancy Rating: C
• Lactation Risk Categories: Probably safe
• Renal Dosing
  • Adult: no adjustment
  • Pediatric: no adjustment
• Hepatic Dosing
  • Adult: not defined
  • Pediatric: not defined

Contraindications

• Allergy to class/drug
• caution if ischemic heart disease
• caution if HTN
• caution if arrhythmias
• caution if hypokalemia
• caution if diabetes mellitus
• caution if seizure disorder
• caution if hyperthyroidism
• caution if pheochromocytoma
• caution if pregnancy
• caution if elderly pts

Adverse Reactions

Serious

• hypersensitivity rxns
• bronchospasm, paradoxical
• HTN
• angina
• MI
• hypokalemia
• arrhythmias

Common

• tremor
• nervousness
• headache
• nausea
• tachycardia
• muscle cramps
• palpitations
• insomnia
• dizziness

Pharmacology

• Half-life: 2.7-6h
• Metabolism: liver, CYP450
• Excretion: urine primarily, feces
• Mechanism of Action: stimulates beta-2 adrenergic receptors, relaxing airway smooth muscle