Dexmedetomidine

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Background

  • Provides sedation with maintenance of arousability, airway protection

General

  • Type: Alpha-2 agonist
  • Dosage Forms:IV
  • Common Trade Names: Precedex (US), Dexdor (European)

Adult Dosing

  • ICU Sedation: 1 mcg/kg over 10 minutes followed by 0.2 to 0.7 mcg/kg/hr
  • Procedural Sedation: 1 mcg/kg over 10 minutes followed by 0.6 mcg/hr titrated to effect, generally 0.2 to 1 mcg/kg/hr

Pediatric Dosing

Special Populations

  • Pregnancy Rating: C
  • Lactation: Unknown if excreted in milk. Exercise caution
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Hypotension
  • Bradycardia

Common

  • Hypotension
  • Bradycardia
  • Dry mouth

Pharmacology

  • Half-life: 2 hours
  • Metabolism: Hepatic
  • Excretion: Renal
  • Mechanism of Action: Selective alpha-2 agonist

See Also

Sedation (Main)

Source

Precedex Drug Information

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