Template:Periorbital Cellulitis Antibiotics

Antibiotics

Outpatient

Treatment recommended for 5-7 days. If signs of cellulitis persist at the end of this period, treatment should be continued until the eyelid erythema and swelling have resolved or nearly resolved.

• TMP/SMX 1-2 double-strength tablets BID OR

- In children: TMP/SMX 8 to 12 mg/kg QD of the TMP component divided every 12 hours

• Clindamycin 300mg Q8H - In children: Clindamycin 30 to 40 mg/kg per day in three to four equally divided doses, maximum 1.8 grams per day

PLUS one of the following agents:

• Amoxicillin 875 mg BID OR

- In children: Amoxicillin 45-90 mg/kg per day divided every 12 hours

• Cefpodoxime 400mg BID OR

- In children: Cefpodoxime 10 mg/kg per day divided every 12 hours, max 200 mg

• Cefdinir 300 mg BID - In children: Cefdinir 14 mg/kg per day, divided every 12 hours, max daily 600 mg

Inpatient

• Vancomycin 15-20mg/kg IV BID + (one of the following)
  • Ampicillin/Sulbactam 3 g IV q6hr OR
  • Ticarcillin/Clavulanate 3.1 g IV q4h OR
  • Piperacillin/Tazobactam 4.5 g IV q6h OR
  • Ceftriaxone 2 g IV q12hr OR
  • Cefotaxime 2 g IV q4h

Pediatric:

• Vancomycin 15mg/kg IV q6hrs + (one of the following)
  • Ampicillin/Sulbactam 50mg/kg IV q6hrs (max 3g/dose) OR
  • Piperacillin/Tazobactam 100mg/kg IV q8hrs (max 4.5g) OR
  • Ceftriaxone 50mg/kg IV q12hrs (max 2g/dose) OR
  • Cefotaxime 50mg/kg IV q6hrs (max 2g/dose)