Template:Heparin reversal

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  • Major bleeding due to unfractionated heparin:
    • 1 mg IV for every 100 units of heparin infused in past 3h
    • Do not infuse faster than 50mg/10min
    • If it has been >30min since last heparin injection, 0.5mg may be sufficient
  • Major bleeding due to low-molecular-weight heparin:
    • Protamine is less effective for bleeding from LMWH than it is with heparin-induced bleeds
    • Enoxaparin: 1 mg IV for every 1 mg enoxaparin administered in past 8h
    • Dalteparin: 1 mg IV for every 100 anti-Xa international units of dalteparin