Antibiotics By Diagnosis (Peds)

Bugs & Drugs

Fever of Uncertain Source (FUS)	Neonatal (0-30 days): GBS, E. coli, Klebsiella, Enterobacter, Listeria or S. aureus (rare)	Send blood, urine and CSF cultures. Listeria, while infrequent at CCHMC, may sporadically occur in clustered cases. Ampicillin 200 mg/kg/day (if >2 kg) IV div Q6 AND Cefotaxime 200 mg/kg/day IV div Q6. Ampicillin 200 mg/kg/day (if >2 kg) IV div Q6 AND Gentamicin 3.5 mg/kg/day IV Q24. Consider risk factors for neonatal HSV disease. Test and treat accordingly.
Fever of Uncertain Source (FUS)	Neonatal (30-60 days): See above.	Workup: Blood and urine specimen. If low-risk (non-ill appearing), normal blood and urine analyses, parents and PMD okay, consider no LP, no antibiotics, and discharge home with f/u in 12-24 hours. Otherwise, LP + Abx. Cefotaxime 200 mg/kg/day IV div Q6 or Ceftriaxone1 100 mg/kg/day IV div Q12. If evidence of UTI or severly ill infant, add Ampicillin.