Sheehan's syndrome
Background
- Also known as postpartum hypopituitarism
- Caused by pituitary hypoperfusion and infarction usually in the setting of postpartum hemorrhage
- During pregnancy there is enlargement of the pituitary gland predisposing it to ischemia in low-flow states
Clinical Features
- Symptoms consistent with adrenal insufficiency, hypothyroidism and hypogonadism
- Inability to lactate
- Amenorrhea or oligomenorrhea
- Fatigue
- Cold intolerance
- Lethargy
- Weight loss
Differential Diagnosis
Evaluation
Workup
Diagnosis
Management
- Currently no treatment is available but there is an ongoing open-label small pilot study looking at using recombinant human prolactin