Simethicone

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Administration

  • Dosage Forms: Cap: 125mg, 180mg; Chew: 80mg, 125mg; Susp: 40mg per 0.6mL
  • Routes of Administration: Oral
  • Common Trade Names: Gas-X

Adult Dosing

  • 40-360 mg PO QID prn flatulence
    • Max: 500mg/day

Pediatric Dosing

  • <2 years old
    • 20mg PO QID prn
      • Max: 240mg/day
  • 2-12 years old
    • 40mg PO QID prn
      • Max: 480 mg/day
  • >12 years old
    • Use adult dosing

Special Populations

Pregnancy Rating

  • May use during pregnancy

Lactation risk

  • No human data available

Renal Dosing

  • Adult: N/A
  • Pediatric: N/A

Hepatic Dosing

  • Adult: N/A
  • Pediatric: N/A

Contraindications

  • Allergy to class/drug
  • Intestinal perforation
  • GI Obstruction

Adverse Reactions

Serious

  • None reported

Common

Pharmacology

  • Half-life: Unknown
  • Metabolism: None
  • Excretion: Feces (100% unchanged)

Mechanism of Action

  • Alters gas bubble surface tension

Comments

See Also

References

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