Propafenone

Administration

• Type:Antiarrhythmics
• Dosage Forms: Oral cap, Oral tablet
• Routes of Administration: PO
• Common Trade Names: Rhythmol

Adult Dosing

Sustained Ventricular Tachycardia

• 150 mg PO q 8 hrs
• Dosage may be increased at 3-4 days to 225 mg PO q 8 hrs
• Max dosage: 300 mg PO q 8 hrs

New Onset Atrial fibrillation

• 450 to 600 mg PO as a single dose

Sinus Rhythm Maintenance in Atrial fibrillation or Atrial flutter

• See sustained VT dosing

PSVT Prophylaxis in AVRT including WPW

• 300 mg q 8 hrs for 48 hrs (max 900 mg q 8 hrs)
• Limited data regarding dosing

Pediatric Dosing

PSVT Prophylaxis in AVRT including WPW

• 8 to 10 mg/kg/day PO in 3 divided doses.
• Increase by 2 to 3 mg/kg/day every 2 to 3 days
• Max 15 mg/kg/day PO in 3 divided doses.

Special Populations

Renal Dosing

• Adult:
• Pediatric:

Hepatic Dosing

• Adult:
• Pediatric:

Contraindications

• Allergy to class/drug
• Significant QRS widening
• High Grade Heart Block
• Heart Failure
• Left Ventricular Dysfunction
• Bradycardia
• Cardiogenic Shock
• Electrolyte Imbalance
• Hypotension
• Sick Sinus Syndrome
• Long QT Syndrome
• Brugada Syndrome
• Renal failure (relative)
• Hepatic failure (relative)
• Asthma
• COPD
• Bronchospasm
• SLE

Pharmacology

• Half-life:
• Metabolism:
• Excretion: