Calciphylaxis

Revision as of 16:50, 20 November 2014 by Kxl328 (talk | contribs) (Created page with "==Background== *Most commonly HD/ESRD patients (1% of ESRD) *No available data in general population (non-uremic calciphylaxis) *Calcium and phosphate levels rise beyond solub...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Background

  • Most commonly HD/ESRD patients (1% of ESRD)
  • No available data in general population (non-uremic calciphylaxis)
  • Calcium and phosphate levels rise beyond solubility and precipitate in arteries
  • May be increasing due to widespread IV vitamin D
  • Mortality as high as 60-80%; sepsis from necrotic skin lesions

Features

  • Very painful lesions develop suddenly and progress rapidly
  • Dermatolgic appearances:
    • Livedo reticularis
    • Stellate purpura
    • Usually LEs, hands, or torso

DDx

  • Brown recluse spider bite
  • Bullous Pemphigoid
  • Cellulitis, necrotizing fasciitis
  • Erythema Nodosum
  • Vasculitis
  • Venous ulcers

Labs

  • Serum PTH level
  • CBC, CMP, phosphate, coags
  • Inpatient - hepatitis panel, cryofibrinogen level, lipase, ESR, CRP, ANA, ANCA

Imaging

Retrieved from "https://www.wikem.org/w/index.php?title=Calciphylaxis&oldid=26211"