EBQ:PEAPETT Study
Sharifi M et al.. "Pulseless electrical activity in pulmonary embolism treated with
thrombolysis (from the “PEAPETT” study)". American Journal of Emergency Medicine. 2016. 34:1963-1967.PubMed Full text
Clinical Question
Does low dose tissue plasminogen activator (tPA) improve survival in patients with pulseless electrical activity and cardiopulmonary arrest due to confirmed pulmonary embolism?
Conclusion
Rapid administration of 50mg of tPA is safe and effective in achieving ROSC in patients with PEA due to massive pulmonary embolism leading to increased survival and reduction of pulmonary artery pressures
Major Points
Approximately 8%-13% of unexplained cardiac arrests are due to a massive pulmonary embolism (PE)[1]. Current ACLS and AHA guidelines suggest that thrombolytics should be considered in cardiac arrests that are thought to be secondary to a PE. This study was created to understand better the usage of tPA, efficacy, and safety in cardiopulmonary arrest in confirmed PE.
Study Design
Population
Patient Demographics
Inclusion Criteria
Exclusion Criteria
Interventions
Outcomes
Primary Outcome
Secondary Outcomes
Subgroup analysis
Criticisms & Further Discussion
External Links
See Also
Funding
References
- ↑ Hess EP, Campbell RL, White RD. Epidemiology, trends, and outcome of out-of hospital cardiac arrest of non-cardiac origin. Resuscitation 2007;72:200–6