Erythema multiforme

Background

Erythema Multiforme

• Erythema Multiforme (EM) is an acute, self-limited skin condition precipitated by a variety of factors:
  • Infections:
    • Viral: HSV, hepatitis, influenza A
    • Fungal: dermatophytosis, histoplasmosis, coccidioidomycosis
    • Bacterial: streptococcus, tuberculosis
  • Drugs:
    • Antibiotics (penicillin, sulfonamides), anticonvulsants (phenytoin, barbiturates), NSAIDS, aspirin, antituberculous meds, allopurinol, etc.
  • Collagen Vascular Disorders:
    • RA, SLE, dermatomyositis, polyarteritis nodosa
  • Others:
    • Pregnancy, cold weather, sunlight, contact exposure, foods, malignancy, hormonal
• Peak incidence in second and third decades of life
• Despite multiple associations, thought to be triggered by HSV in most cases
• Usually self-limited and resolves within 2-6 weeks; may recur
• Wide spectrum of severity
  • Classified as Erythema multiforme minor or Erythema multiforme major