Osteosarcoma

Background

• Most common primary pediatric bone tumor
  • 3% of all childhood cancers
• Around two-thirds of those diagnosed with non-metastatic disease under the age of 40 will be long-term survivors or cured of the disease with appropriate treatment
• Survival is less than 20 percent with metastatic disease
• Bimodal as it peaks in early adolescence and over the age of 65

Pathophysiology

• Overproduction of osteoid and immature bone by malignant osteoblasts