Drug rash

Background

ABCs of Drug Rashes

• Acute generalized exanthematous pustulosis (AGEP)
• Bullous disease, drug induced
• Captopril (ACE-inhibitor) induced angioedema
• Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
• SJS/TEN

Clinical Features

• Sudden, usually morbilliform, often starts on face & trunk & spreads
• More polymorphous than viral exanthem

Morbilliform drug eruption on back

Differential Diagnosis

Other Rash

• Acute generalized exanthematous pustulosis
• Allergic reaction
• Aphthous stomatitis
• Atopic dermatitis
• Coxsackie
• Dermatitis herpetiformis
• Exfoliative erythroderma
• Impetigo
• Pellagra
• Pityriasis rosea
• Serum Sickness
• Tinea capitus
• Tinea corporis
• Vitiligo

Management

• Discontinue offending agent
• Supportive
• Topical steroids may help relieve pruritus

See Also

• Rashes