ACS - Risk Stratification

Vancouver Chest Pain Rule

• Sensitivity of the rule was 95.1%, specificity was 56.3%, positive prediction value was 25.9%, and negative prediction value was 98.6%.
• 30 day outpatient ACS rate in discharge patients according to the rule is 1.2%
• The following patients can be discharged with outpatient followup

<40 yrs old

• Normal initial ECG (T-wave flattening is okay)
• No prior history of ischemic chest pain

>40yr

• Normal initial ECG (T-wave flattening is okay)
• No prior history of ischemic chest pain
• Low risk chest pain characteristics (i.e. pain not radiating or pain that increases with deep breath or pain that increases with palpation)
• Initial CK-MB < 3
  • If initial CK-MB >3 pt can still be discharged as long as repeat biomarkers/ECG 2hrs later shows no increase/changes

Likelihood That Signs/Symptoms Represent ACS due to CAD

Feature	High Likelihood (any of the following)	Intermediate Likelihood (absence of high-likelihood features and presence of any of the following)	Low Likelihood (absence of high- or intermediate-likelihood features but may have)
History	Chest or left arm pain or discomfort as chief symptom reproducing prior documented angina	Chest or left arm pain or discomfort as chief symptom	Probable ischemic symptoms in absence of any of the intermediate-likelihood characteristics
	Known history of coronary artery disease, including myocardial infarction	Age >70 y old	Recent cocaine use
		Male sex
		Diabetes mellitus
Examination	Transient mitral regurgitation murmur, hypotension, diaphoresis, pulmonary edema, or rales	Extracardiac vascular disease	Chest discomfort reproduced by palpation
ECG	New, or presumably new, transient ST-segment deviation (1 mm or greater) or T-wave inversion in multiple precordial leads	Fixed Q waves	T-wave flattening or inversion <1 mm in leads with dominant R waves
		ST depression 0.5–1.0 mm or T-wave inversion >1 mm
			Normal ECG
Cardiac markers	Elevated cardiac troponin I, troponin T, or MB fraction of creatine kinase	Normal	Normal

Short-Term Risk of Death or Nonfatal Myocardial Infarction by Risk Stratification in Patients with Unstable Angina

Feature	High Likelihood (at least one of the following features must be present)	Intermediate Likelihood (no high-risk feature, but must have one of the following)	Low Likelihood (no high- or intermediate-risk feature, but may have any of the following)
History	Accelerating tempo of ischemic symptoms in preceding 48 h	Prior myocardial infarction, peripheral or cerebrovascular disease, or coronary artery bypass grafting; prior aspirin use	—
Character of the pain	Prolonged ongoing (>20 min) rest pain	Prolonged (>20 min) rest angina, now resolved, with moderate or high likelihood of CAD	Increased angina frequency, severity, or duration
		Rest angina (>20 min) or relieved with rest or sublingual nitroglycerin	Angina provoked at a lower threshold
			New-onset angina with onset 2 wk to 2 mo before presentation
		Nocturnal angina
		New-onset or progressive Canadian Cardiology Society Class III or IV angina in the past 2 wk without prolonged (>20 min) rest pain but with intermediate or high likelihood of CAD;
Clinical findings	Pulmonary edema, most likely due to ischemia	Age >70 y old	Chest discomfort reproduced by palpation
	New or worsening mitral regurgitation murmur
	S3 or new/worsening rales
	Hypotension, bradycardia, tachycardia
	Age >75 y old
ECG	Angina at rest with transient ST-segment changes >0.5 mm	T-wave changes, pathologic Q waves, or resting ST depression <1 mm in multiple lead groups (anterior, inferior, lateral)	Normal or unchanged ECG
	Bundle-branch block, new or presumed new
	Sustained ventricular tachycardia
Cardiac markers	Elevated cardiac TnT, TnI, or CK-MB (e.g., TnT or TnI >0.1 nanogram/mL)	Slightly elevated cardiac TnT, TnI, or CK-MB (e.g., TnT >0.01 but <0.1 nanogram/mL)	Normal

TIMI Risk Stratification Score

NSTEMI TIMI Score

Used to estimate percent risk of all-cause mortality, new/recurrent MI, or need for revascularization at 14 days

• Age >65 yrs (1 point)
• Three or more risk factors for coronary artery disease: (1 point)
  • family history of coronary artery disease
  • hypertension
  • hypercholesterolaemia
  • diabetes
  • current smoker
• Use of aspirin in the past 7 days (1 point)
• Significant coronary stenosis (stenosis >50%) (1 point)
• Severe angina (e.g., >2 angina events in past 24 h or persisting discomfort) (1 point)
• ST-segment deviation of ≥0.05 mV on first ECG (1 point)
• Increased troponin and/or creatine kinase-MB blood tests (1 point)

TIMI Risks

points	% risk of mortality, MI, or need for revascularization
0	5%
1	5%
2	8%
3	13%
4	20%
5	26%
6	41%

See Also

Acute Coronary Syndrome (Main) ADAPT Trial

Source

• 2007 ACC/AHA Guidelines for the Management of Patients with UA/NSTEMI
• Walker N. Characteristics and outcomes of young adults who present to the emergency department with chest pain. Acad Emerg Med. 2001 Jul;8(7):703-8.