Streptomycin
General
- Type: Aminoglycosides
- Dosage Forms:
- IM
Adult Dosing
Infections, Bacterial
- 1-2 g/day IM divided q6-12h
- Max: 2 g/day; Info: adjust dose based on serum levels
- Renal dosing
- Creatinine Clearance 50-80: give q24h
- Creatinine Clearance 10-50: give q24-72h
- Creatinine Clearance <10: give q72-96h
Active tuberculosis
- 15 mg/kg IM q24h 5-7x/wk
- Alternative: 25-30 mg/kg IM 2-3x/wk
Plague
- 1g IM q12h x10 days
- Maximum dose: 2 g/day (adjust dose based on serum levels)
Tularemia
- 1g IM q12h x10 days
- Maximum dose: 2 g/day (adjust dose based on serum levels)
Pediatric Dosing
Infections, Bacterial
- 20-40 mg/kg IM q24h
- Alternative: 20-40 mg/kg IM 2x/wk
- Maximum dose: 1 g/dose if q24h, or 1.5 g/dose if 2x/wk
- Renal dosing
- Creatinine Clearance 50-80: 7.5 mg/kg give q24h
- Creatinine Clearance 10-50: 7.5 mg/kg give q24-72h
- Creatinine Clearance <10: 7.5 mg/kg give q72-96h
Active tuberculosis
- 20-40 mg/kg IM q24h
- Alternative: 20-40 mg/kg IM 2x/wk
- Maximum dose: 1 g/dose if q24h, or 1.5 g/dose if 2x/wk
Plague
- 15 mg/kg IM q12h x10 days
- Maximum dose: 2 g/day (adjust dose based on serum levels)
- Maximum dose: 2 g/day (adjust dose based on serum levels)
Tularemia
- 15 mg/kg IM q12h x10 days
Contraindications / cautions
- caution if hypersensitivity to sulfites
- caution if impaired vestibular function
- caution if impaired auditory function
- caution if concurrent ototoxic agents
- caution if concurrent neurotoxic agents
- caution if neuromuscular disease
- caution if renal impairment
- caution if dehydration
- caution if concurrent nephrotoxic agent use
- caution if electrolyte abnormalities
- caution if prolonged use
- caution in neonates or infants
- caution in elderly patients